abstract：:Borna disease (BD) virus, a still unclassified neurotropic agent, causes either fatal encephalomyelitis or persistent asymptomatic infection in a variety of animal species. We monitored the neuronal functions of intracerebrally infected but healthy rats with three types of learning experiments. Spatial discrimination ...

journal_title：Biological psychiatry

authors： Dittrich W,Bode L,Ludwig H,Kao M,Schneider K

更新日期：1989-12-01 00:00:00

abstract：:The relation of stress to cancer is the subject of considerable controversy. We studied the possible influence of chronic stress on the time of development and frequency of tumors induced in rats after a single exposure to ethylnitrosourea during prenatal life. Time of development, localization, incidence, type, and s...

journal_title：Biological psychiatry

authors： Sotelo J,Palencia G,Rosas N,Perez R

更新日期：1989-11-01 00:00:00

abstract：:The densities of platelet 3H-imipramine sites were determined by repetitive measures of 11 normal controls over the course of 1 year. A significant seasonal variation was found, with a circannual peak on February 17 and a nadir on August 18. The estimated amplitude of this rhythm was +/- 599.54 fmol/mg, which fluctuat...

journal_title：Biological psychiatry

authors： DeMet EM,Chicz-DeMet A,Fleischmann J

更新日期：1989-09-01 00:00:00

abstract：:Unmedicated chronic schizophrenic inpatients and nonpsychotic controls were tested in a paradigm designed to elicit habituated event-related potentials (ERPs) to auditory stimuli. Analysis of Variance of the ERP components recorded at bilateral frontal (F1 and F2) and temporal (T3 and T4) scalp leads revealed signific...

journal_title：Biological psychiatry

authors： Kessler C,Steinberg A

更新日期：1989-08-01 00:00:00

abstract：:A number of neuroendocrine abnormalities have been reported in panic disorder patients: the most extensively studied being disturbances of hypothalamic-pituitary-adrenal function (Curtis et al. 1982; Leiberman et al. 1983; Uhde et al. 1988). The recent sequencing and synthesis of corticotropin-releasing hormone now al...

journal_title：Biological psychiatry

authors： Rapaport MH,Risch SC,Golshan S,Gillin JC

更新日期：1989-08-01 00:00:00

abstract：:The efficacy of gamma-hydroxybutyrate (GHB) versus placebo for treating narcolepsy was evaluated in 20 patients with narcolepsy, 10 men and 10 women, using a double-blind counterbalanced crossover design. Each patient completed a daily sleep-wake log and questionnaire during a 14-day baseline, a 29-day placebo period,...

journal_title：Biological psychiatry

authors： Scrima L,Hartman PG,Johnson FH Jr,Hiller FC

更新日期：1989-08-01 00:00:00

abstract：:This article describes a group of 10 hospitalized, mentally retarded patients with rapid cycling affective disorders, including details of demography, pattern of illness, and response to an open trial of treatment with lithium and/or carbamazepine. Family histories of these patients revealed high rates of mental illne...

journal_title：Biological psychiatry

authors： Glue P

更新日期：1989-07-01 00:00:00

abstract：:Stable schizophrenic and schizoaffective outpatients underwent abrupt withdrawal from a fixed dose of neuroleptic. Prolactin concentrations were determined preceding and following drug withdrawal. Basal prolactin concentrations were significantly lower 3, 4, or 5 days following drug withdrawal than on subsequent days....

journal_title：Biological psychiatry

authors： Kirkpatrick B,Buchanan RW,Maeda K,Carpenter WT Jr,Jauch D,Tamminga CA

更新日期：1989-06-01 00:00:00

abstract：:This paper reports the phenomenon of dependence to a somatostatin octapeptide analog used for the treatment of acromegaly and severe headache. The mechanism of this dependence is still unknown, but could be based on the interaction of the somatostatin analog with opioid receptors. Analgesia may be at least partially s...

journal_title：Biological psychiatry

authors： Paunović VR,Popović V

更新日期：1989-05-01 00:00:00

abstract：:Temporal lobe glucose metabolic rate was assessed in 21 off-medication patients with schizophrenia and 19 normal controls by positron emission tomography with 18F-deoxyglucose. Patients with schizophrenia had significantly greater metabolic activity in the left than the right anterior temporal lobe, and the extent of ...

journal_title：Biological psychiatry

authors： DeLisi LE,Buchsbaum MS,Holcomb HH,Langston KC,King AC,Kessler R,Pickar D,Carpenter WT Jr,Morihisa JM,Margolin R

更新日期：1989-04-01 00:00:00

abstract：:Cerebrospinal fluid beta-endorphin-like immunoreactivity (CSF BLI) was determined for 69 patients who met DSM-III criteria for delirium and for 8 controls. The CSF BLI was significantly lower in the delirious patient group than in the controls (12.5 +/- 3.0 pg/ml versus 15.0 +/- 3.4 pg/ml, p less than 0.05). CSF BLI h...

journal_title：Biological psychiatry

authors： Koponen H,Stenbäck U,Mattila E,Reinikainen K,Soininen H,Riekkinen PJ

更新日期：1989-04-01 00:00:00

abstract：:Twenty-three inpatients who met DSM-III criteria for schizophrenia were selected for cerebrospinal fluid (CSF) neurochemical study of tardive dyskinesia (TD). Ten inpatients had tardive dyskinesia, and the remaining 13 patients without TD served as controls. There were no intergroup differences in sex, age, duration o...

journal_title：Biological psychiatry

authors： Lu RB,Ko HC,Lin WL,Lin YT,Ho SL

更新日期：1989-03-15 00:00:00

abstract：:An early-onset, familial form of Alzheimer's disease (AD) has been reported to be linked to a locus on the long arm of chromosome 21 (21q21). Furthermore, duplications in the vicinity of this locus involving the beta-amyloid gene and the proto-oncogene ets-2 have been reported in association with AD. The structural ge...

journal_title：Biological psychiatry

authors： Zubenko GS,Sauer P

更新日期：1989-03-15 00:00:00

abstract：:Auditory evoked potentials were recorded using a paired click, conditioning-testing paradigm in 10 schizophrenics and in 10 normal subjects with no family history of psychotic disorder. The paradigm is used to demonstrate central nervous system gating of responsiveness to auditory stimuli by examining the extent to wh...

journal_title：Biological psychiatry

authors： Nagamoto HT,Adler LE,Waldo MC,Freedman R

更新日期：1989-03-01 00:00:00

abstract：:Delirium, also known as acute confusional state, is a common reversible organic psychiatric syndrome. This paper focuses on toxic delirium associated with prominent paroxysmal electroencephalogram (EEG) dysfunction occurring in nonepileptic patients. Our data derive from observations in two conditions, viz., delirium ...

journal_title：Biological psychiatry

authors： van Sweden B,Mellerio F

更新日期：1989-02-15 00:00:00

abstract：:This article demonstrates methods by which receiver operating characteristics (ROC) analysis may be used to evaluate and improve the Dexamethasone Suppression Test (DST). ROC indices provide a description of nonbinary diagnostic tests that is independent of any particular cutoff and that allows investigators to use ri...

journal_title：Biological psychiatry

authors： Mossman D,Somoza E

更新日期：1989-01-15 00:00:00

abstract：:Plasma norepinephrine (NE), free 3-methoxy-4-hydroxyphenethylene glycol (MHPG), and binding of tritiated yohimbine to platelet membranes were measured in 14 patients with generalized anxiety disorder (GAD), who were matched for age and sex with 14 patients with unipolar major depressive disorder (MDD) and 14 normal su...

journal_title：Biological psychiatry

authors： Sevy S,Papadimitriou GN,Surmont DW,Goldman S,Mendlewicz J

更新日期：1989-01-15 00:00:00

abstract：:Serum free thyroxine (FT4), total thyroxine (TT4), and Brief Psychiatric Rating Scale (BPRS) measurements were obtained following hospital admission and at 2-week intervals during hospitalization in 80 male psychiatric inpatients with a variety of major psychotic and affective disorders. A strong correlation between t...

journal_title：Biological psychiatry

authors： Southwick S,Mason JW,Giller EL,Kosten TR

更新日期：1989-01-01 00:00:00

abstract：:The current concept that blunted adrenocorticotropic hormone (ACTH) response to human corticotropin-releasing-hormone (h-CRH) in depression is primarily determined by elevated circulating plasma cortisol levels is still unproven. We tested this hypothesis by comparing ACTH release following intravenous administration ...

journal_title：Biological psychiatry

authors： von Bardeleben U,Stalla GK,Müller OA,Holsboer F

更新日期：1988-11-01 00:00:00

abstract：:The volume of the entorhinal region is significantly reduced in postmortem brains of schizophrenics compared with controls (p less than 0.017). In addition, a significant reduction of neurons (p less than 0.017), but no significant increase in absolute glial cell numbers, is found. These results are consistent with th...

journal_title：Biological psychiatry

authors： Falkai P,Bogerts B,Rozumek M

更新日期：1988-09-01 00:00:00

abstract：:Extracellular serotonin in striatum was studied in untreated streptozotocin-induced diabetic rats and in untreated nondiabetic rats that served as age-, food-, and sex-matched controls. Extracellular serotonin was studied under anesthesia in vivo and dynamically with voltammetry. The results showed that an early and s...

journal_title：Biological psychiatry

authors： Broderick PA,Jacoby JH

更新日期：1988-06-01 00:00:00

abstract：:Urinary MHPG concentrations and platelet 3H-imipramine binding (Bmax, Kd) were measured in 20 psychiatric inpatients with diagnoses of major depressive disorder. Clinical assessments were performed using the Present State Examination (PSE) interview, and several dimensions of symptomatology were constructed on the bas...

journal_title：Biological psychiatry

authors： Carr V,Edwards J,Prior M

更新日期：1988-03-15 00:00:00

abstract：:Single-unit recording techniques and liquid chromatography with electrochemical detection were used to measure the effects of neuroleptic pretreatment on the efficacy of dopamine transmission in the amygdaloid complex. Rats received twice-daily injections of clozapine (10.0 mg/kg), haloperidol (1.0 mg/kg), or vehicle ...

journal_title：Biological psychiatry

authors： Anderson GD,Rebec GV

更新日期：1988-03-01 00:00:00

abstract：:The effects of short- and long-term administration of a low dose of tranylcypromine on brain and urine levels of several biogenic amines and on brain activity of monoamine oxidases (MAO) A and B were investigated. MAO-A and MAO-B were inhibited by greater than 85% on day 1, and this inhibition continued to increase ov...

journal_title：Biological psychiatry

authors： Hampson DR,Baker GB,Coutts RT

更新日期：1988-02-01 00:00:00

abstract：:This study is designed to measure effects of serotonin 1A (5-HT1A) agonists on escape deficits produced by inescapable shock in rats--a model of learned helplessness. Rats were first exposed to 60 inescapable shocks (15-sec duration, 0.8 mA, every 1 min +/- 15 sec), and 48 hr later, they were subjected to daily 15-min...

journal_title：Biological psychiatry

authors： Giral P,Martin P,Soubrié P,Simon P

更新日期：1988-02-01 00:00:00

abstract：:Defatted breast milk from women with postpartum psychosis and from healthy lactating women was analyzed by high-resolution gel permeation chromatography as well as by sodium dodecyl sulfate (SDS) and urea polyacrylamide gel electrophoresis. The gel permeation procedure allowed quantitative analysis of milk proteins (i...

journal_title：Biological psychiatry

authors： Nyberg F,Lindström LH,Terenius L

更新日期：1988-01-15 00:00:00

abstract：:Covariance of brain electrical activity (EEG), plasma adrenocorticotrophic hormone (ACTH) and cortisol levels, and mood states were determined for healthy adult men during the first 2 hr after ingestion of ethanol or ethanol placebo under controlled double-blind conditions. Analysis of integrated plasma ACTH and corti...

journal_title：Biological psychiatry

authors： Lukas SE,Mendelson JH

更新日期：1988-01-15 00:00:00

abstract：:This prospective study included 32 patients with primary hyperparathyroidism (HPT). As compared with a healthy reference group, the patients had pronounced psychiatric symptomatology [CPRS score 17.2 +/- 9.0 (SD) versus 4.4 +/- 2.0], which was mainly affective in character. The severity of symptoms was not related to ...

journal_title：Biological psychiatry

authors： Joborn C,Hetta J,Rastad J,Agren H,Akerström G,Ljunghall S

更新日期：1988-01-15 00:00:00

abstract：:We have investigated the dexamethasone suppression of cortisol release in a group of 28 patients with senile dementia of the Alzheimer type (SDAT) after stimulation by physostigmine and clonidine, as compared with basal conditions. All patients but one had previously been evaluated with a depression symptom checklist ...

journal_title：Biological psychiatry

authors： Davous P,Roudier M,Piketty ML,Abramowitz C,Lamour Y

更新日期：1988-01-01 00:00:00

abstract：:Eighteen unmedicated patients suffering from major depressive disorder with melancholia (DSM-III) were examined for abnormalities in peripheral serotonin (5-HT) and related metabolites. Serotonin in platelet-free plasma and in platelets from melancholics was significantly reduced to 30% and 60% of their respective con...

journal_title：Biological psychiatry

authors： Sarrias MJ,Artigas F,Martínez E,Gelpí E,Alvarez E,Udina C,Casas M

更新日期：1987-12-01 00:00:00

abstract：:The effect of oral contraceptive use and hospitalization stress on the results of the dexamethasone suppression test (DST) were assessed. This test, in which 1 mg dexamethasone is given at 11:00 p.m., and blood cortisol is analyzed the following day, is used as an indicator or major or endogenous depression, as oppos...

journal_title：Biological psychiatry

authors： D'haenen H,de Weert D,Ansseau M

更新日期：1987-12-01 00:00:00

abstract：:Acetylcholinesterase (AChE) from erythrocytes was solubilized by Triton X-100. Size and charge heterogeneity of AChE was investigated by polyacrylamide gel electrophoresis (PAGE) and isoelectric focusing (IEF) in polyacrylamide gels in the presence of 0.5% (v/v) Triton X-100. There were no interindividual differences ...

journal_title：Biological psychiatry

authors： Fritze J,Beckmann H

更新日期：1987-09-01 00:00:00

abstract：:Circling behavior is one of the best understood behaviors in animals. It is, for the most part, dopaminergically mediated and related to asymmetry in dopaminergic activity between the left and right basal ganglia or left and right frontal cortex. As a rule, animals rotate toward the hemisphere with lower striatal dopa...

journal_title：Biological psychiatry

authors： Bracha HS

更新日期：1987-08-01 00:00:00

abstract：:A nutritional survey, the Pittsburgh Appetite Test (PAT), was developed to study potential changes in appetite and food preference reported by patients during a depressive episode and during antidepressant treatment. We examined a group of 50 depressed outpatients who were drug-free for 2 weeks prior to treatment with...

journal_title：Biological psychiatry

authors： Fernstrom MH,Krowinski RL,Kupfer DJ

更新日期：1987-05-01 00:00:00

abstract：:Neuroendocrine functions in depressed patients with major affective disorders were serially investigated by the Dexamethasone Suppression Test (DST), the thyrotropin-releasing hormone (TRH) stimulation test, and the plasma TRH-like immunoreactivity (TRH-LI) measurement. Prior to antidepressant therapy, the sensitivity...

journal_title：Biological psychiatry

authors： Itoh N,Matsui N,Fuwano S,Yaginuma H,Miyashita O,Sakai M

更新日期：1987-05-01 00:00:00

abstract：:Elevated plasma vasopressin concentrations have been documented in antipsychotic drug-treated patients as well as a drug-free acutely psychotic patients. To evaluate the effects of antipsychotic drugs on plasma vasopressin, we measured vasopressin response to a single dose of intramuscular chlorpromazine or intravenou...

journal_title：Biological psychiatry

authors： Raskind MA,Courtney N,Murburg MM,Backus FI,Bokan JA,Ries RK,Dorsa DM,Weitzman RE

更新日期：1987-04-01 00:00:00

abstract：:Psychomotor retardation is a frequently observed clinical feature of depressive states. This study attempted to assess the relationship between response slowness and central nervous system (CNS) activity by examining cortical evoked potentials (EPs) during psychomotor task performance. Patients consisted of 21 women w...

journal_title：Biological psychiatry

authors： Knott VJ,Lapierre YD

更新日期：1987-03-01 00:00:00

abstract：:Anxious patients, and more specifically, patients experiencing panic attacks, are thought to have a significant biological component to their illness. This study looks at two promising biological markers associated with this patient population-mitral valve prolapse and lactate-induced panic. We present our findings, w...

journal_title：Biological psychiatry

authors： Dager SR,Cowley DS,Dunner DL

更新日期：1987-03-01 00:00:00

abstract：:Dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis, demonstrated by failure to suppress cortisol secretion after dexamethasone, is found in approximately 50% of patients with major depression (MD). In this study, we examined the response of adrenocorticotrophic hormone (ACTH) and cortisol to insulin-induced ...

journal_title：Biological psychiatry

authors： Lopez JF,Kathol RG,Jaeckle RS,Meller W

更新日期：1987-02-01 00:00:00

abstract：:We investigated the computerized electroencephalography (cEEG) in a group of 85 normal adolescents. The spatial frequency of the cEEG was analyzed using various multivariate statistical techniques. The factor analyses revealed three factors that accounted for most of the variability in the data and that could be inter...

journal_title：Biological psychiatry

authors： Volkow ND,Gomez-Mont F,Inamdar S,Lamella M,Prichep L,John R

更新日期：1987-02-01 00:00:00